Facts about Circadian Rhythm
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Jeffrey Hall, Michael Rosbash, and Michael Young won the 2017 Nobel Prize in Physiology or Medicine for discovering the PER gene's role in circadian timekeeping in fruit flies.
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Cortisol levels follow a circadian rhythm, peaking shortly after waking in what is known as the cortisol awakening response.
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In humans, core body temperature follows a circadian rhythm, dropping to its lowest point in the early morning hours before wake time.
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Disruption of circadian rhythm, such as from shift work or jet lag, is associated with increased risks of metabolic disorders, cardiovascular disease, and certain cancers.
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Light exposure is the primary zeitgeber, or time cue, that synchronizes the human circadian rhythm to the external environment.
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The circadian rhythm operates on an approximately 24-hour cycle and is regulated by a master clock located in the suprachiasmatic nucleus of the hypothalamus.