Facts about X-Linked Human Anomalies

1. 05

   Rett syndrome, an X-linked dominant disorder caused by mutations in the MECP2 gene, almost exclusively affects females, as males with the mutation rarely survive.

   X-Linked Human AnomaliesJun 6sharegeneticsneurologydisease
2. 04

   Fragile X syndrome, an X-linked condition caused by expansion of a CGG repeat in the FMR1 gene, is the most common inherited cause of intellectual disability.

   X-Linked Human AnomaliesJun 6sharegeneticsneurologyinheritance
3. 03

   Duchenne muscular dystrophy, an X-linked recessive condition caused by mutations in the dystrophin gene, is one of the most common fatal genetic disorders affecting boys.

   X-Linked Human AnomaliesJun 6sharegeneticsdiseaseinheritance
4. 02

   Color blindness, a common X-linked recessive condition, affects approximately 8% of males but only about 0.5% of females worldwide.

   X-Linked Human AnomaliesJun 6sharegeneticsvisionbiology
5. 01

   Hemophilia A, an X-linked recessive bleeding disorder caused by deficiency of clotting factor VIII, affects males far more frequently than females.

   X-Linked Human AnomaliesJun 6sharegeneticsdiseasebiology