Facts about Grey's Anatomy
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Over 300 interns, residents, and attendings have died in Grey's Anatomy storylines across its 21 seasons, with major character deaths including George O'Malley in season 3 and Lexie Grey in season 8.
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Spinoff series Private Practice, featuring Addison Montgomery, ran for six seasons after the character departed Grey's Anatomy in 2007.
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Shonda Rhimes based the title character Meredith Grey partly on her own experiences, and the show popularized the phrase 'McDreamy' in pop culture.
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Set in the fictional Grey Sloan Memorial Hospital in Seattle, Grey's Anatomy was created by Shonda Rhimes and follows surgical interns navigating medicine and personal lives.
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Ellen Pompeo has earned over 575 million dollars across her 21-season run as lead character Meredith Grey, making her one of television's highest-paid actors.
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The show premiered on ABC in March 2005 and has run for 21 seasons, making it one of the network's longest-running dramas.