Facts about Ventromedial Prefrontal Cortex

1. 05

   Lesions to the ventromedial prefrontal cortex are associated with pathological gambling and an inability to learn from negative feedback, a pattern captured by the Iowa Gambling Task.

   Ventromedial Prefrontal CortexJun 6shareneurosciencecognitionpsychology
2. 04

   Reward-based learning and the valuation of outcomes rely heavily on the ventromedial prefrontal cortex, which encodes subjective value signals during economic choice.

   Ventromedial Prefrontal CortexJun 6shareneurosciencecognitionreward
3. 03

   Extinction of conditioned fear memories depends critically on the ventromedial prefrontal cortex, which suppresses amygdala activity during fear extinction learning.

   Ventromedial Prefrontal CortexJun 6shareneurosciencememoryfear
4. 02

   Damage to the ventromedial prefrontal cortex, as studied in patients like Phineas Gage, impairs social judgment while leaving general intelligence largely intact.

   Ventromedial Prefrontal CortexJun 6shareneurosciencepsychologylesion
5. 01

   The ventromedial prefrontal cortex plays a central role in decision-making, emotional regulation, and processing risk and fear responses.

   Ventromedial Prefrontal CortexJun 6shareneurosciencecognitionemotion